Within-group effects ranged from Hedges's g = 0.32-0.99. There was significant heterogeneity between studies for main outcomes and depression. We found small effects favoring IPDT compared to inactive control conditions for main outcomes (g = 0.44), depression (g = 0.46), anxiety (g = 0.20), and quality of life (g = 0.40). The total number of participants was 528 in the treatment group and 552 in the control conditions. Following literature searches, we identified seven studies meeting inclusion criteria. To test the efficacy of internet-delivered psychodynamic therapy (IPDT), we conducted a systematic review and meta-analysis of randomized controlled trials. The study is registered at ISRCTN, ISRCTN12552584.Recent years have seen an increase of internet-delivered interventions based on psychodynamic treatment models.

A non-inferiority margin of Cohen's d=0♳0 was predefined. Primary analyses were based on an intention-to-treat sample including all participants randomly assigned. The primary outcome was change in depression severity measured weekly by the QIDS-A17-SR. Both interventions comprised eight self-help modules delivered over 10 weeks on a secure online platform. Participants were randomly assigned to ICBT or IPDT. Adolescents who scored 9 or higher on the Quick Inventory of Depressive Symptomatology for Adolescents (QIDS-A17-SR) in an initial online screening were contacted by telephone for a diagnostic assessment using the Mini International Neuropsychiatric Interview. Participants were recruited nationwide in Sweden through advertisements on social media, as well as contacts with junior and senior high schools, youth associations, social workers, and health-care providers.

Eligible participants were 15–19 years old, presenting with a primary diagnosis of MDD according to DSM-5.

In this randomised, clinical trial, we tested whether IPDT was non-inferior to ICBT in the treatment of adolescent MDD.

Ipdt test